methylation of dna

Objective: Methylene tetrahydrofolate reductase ( MTHFR) is a key enzyme in the metabolism of folic acid and plays an important role in the methylation of DNA.

目的观察叶酸代谢的关键酶亚甲基四氢叶酸还原酶（MTHFR）基因C677T、A1298C多态与乳腺癌患者对化疗敏感性的关系。

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It is believed that DNA methylation has important functions in gene imprinting, for transposons and in vivo retrovirus silencing as well as the stability of the genome;

现在普遍认为DNA的甲基化的功能是参与许多印记基因、失活的X染色体上的基因、转座子和内源的反转录病毒的沉默。

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There are several types of epigenetic inheritance systems methylation of DNA, RNA interference, histone acetylation and protein modification.

目前发现有如下几种表观遗传分子机制：DNA甲基化，RNA干扰，组蛋白乙酰化和组蛋白修饰。

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Methylation and demethylation of DNA are the complementary processes of epigenetic regulation. Methylation and demethylation influence a diverse array of cellular activities, including X chromosome inactivation, genomic imprinting, chromatin modification, and the silencing of endogenous genes.

DNA甲基化与去甲基化是表观遗传调控的两种重要调节方式，其在X染色体失活、基因组印迹、染色质修饰和内源性基因沉默等过程中发挥重要作用。

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Methylation of cytosine bases in DNA provides a layer of epigenetic control in many eukaryotes that has important implications for normal biology and disease.

DNA中胞嘧啶碱基的甲基化在很多真核细胞中提供了一层表观控制，它对于正常生物学和疾病有着重要的意义。

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Therefore, maternal deficiency of folic acid in pregnancy can finally cause development of fetal trisomy 21 syndrome by its effect on the methylation of DNA in oocyte during secondary meiotic division.

故妊娠期母体叶酸缺乏可能通过影响DNA甲基化最终导致胎儿21-三体综合征的发生。

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RP ion-pair HPLC determination of methylation level of DNA of Chinese Cabbage

白菜DNA甲基化水平的反相离子对高效液相色谱法研究

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Studies on many aspects show that there are four main reasons which cause the epigenetic effects; the methylation of DNA, the acetylation of histones, the change of chromatin structure and the alteration of protein configuration.

多方面的研究表明，导致后生效应的可能原因主要有四个方面：DNA的甲基化、组蛋白的乙酰化、染色质结构背景的改变和蛋白质构型的变化。

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To test whether DNA methylation plays a role in somaclonal variation, the calli were treated with 5-azacytidine that reduces cytosine methylation by blocking activity of DNA methyltransferase.

为了检测DNA甲基化在体细胞克隆多样性中的作用，愈伤组织用5-氮胞苷进行处理，5-氮胞苷通过抑制DNA甲基转移酶的活性降低胞嘧啶的甲基化水平。

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The methylation of DNA can suppress the anti-oncogene in malignancy hematologic disease, which is one of the mechanisms in malignancy hematologic disease and related with prognosis intimate.

DNA甲基化能够抑制多种恶性血液病抑癌基因的表达，是恶性血液病发病的机制之一，并与预后密切相关。

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Under exposing to heavy metal ions, there happens change of the total methylation level of the fish DNA.

在重金属离子的暴露作用下，鲫鱼DNA总甲基化水平发生变化。

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Conclusions As an upstream regulator, PASG can regulate expression of a series of cell proliferation, differentiation relevant downstream genes through changing methylation levels of genomic DNA.

结论PASG基因作为上游调控基因，通过改变基因组甲基化水平调控下游一系列细胞增殖分化相关基因表达。

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The two primary changes of epigenetic mechanism are the DNA methylation and the histone modification.

表观遗传改变的两个最主要机制就是DNA甲基化和组蛋白修饰。

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The methylation of genomic DNA in liver and brain nuclei of aging rats was analysed By Reverse-phase high-performance chromatography ( HPLC) and restriction endonuclease Hpa ⅱ and Msp ⅰ.

用MspⅠ／HpaⅡ酶解电泳法和高效液相色谱（HPLC）两种方法进行比较，研究了不同年龄大鼠的肝、脑细胞基因组DNA的甲基化程度。

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Recent studies suggest that methylation of DNA can act as a "footprint" reflecting the consequence of environmental exposures on different types of cells.

近来研究表明DNA甲基化可以作为反映环境对不同种类的细胞影响的印记。

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Methylation of Genomic DNA and Proto-oncogene c-Ha-ras in Brain Nuclei of Ageing Rats

大鼠衰老过程中脑细胞DNA与c－Ha－ras原癌基因的甲基化

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The effect of methylation level of DNA templates on the transcriptional activity of RNA polymerase from rat liver in vitro

模板甲基化水平对鼠肝RNA聚合酶体外转录活性的影响

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Epigenetic mechanisms, including DNA methylation, histone modification and chromatin remodeling, have been demonstrated to be involved in the development of SLE.

表观遗传学涉及的机制主要包括DNA甲基化和组蛋白修饰及染色质重塑。

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Deficiency of folic acid may cause damage, instability and abnormal methylation of DNA, which could bring about in carcinogenesis.

叶酸缺乏可以引起DNA损伤、不稳定及甲基化异常，这些变化均可引起肿瘤的发生。

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Small RNAs can guide posttranscriptional degradation of complementary messenger RNAs and, in plants, transcriptional gene silencing by methylation of homologous DNA sequences.

小RNA能诱导互补信使RNA在转录后降解，对于植物，可通过同源DNA序列甲基化使转录基因沉默。

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The function of plant genomes depends on chromatin marks such as the methylation of DNA and the post-translational modification of histones.

植物基因组的功能依赖于染色质标记，诸如DNA的甲基化和组蛋白的转录后修饰。

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Mobilization of Transposons m Ping, Ping and Pong and Heritable Alterations in DNA Methylation Pattern Induced by Laser Irradiation in Rice

激光辐射诱导水稻转座子mPing，Ping及Pong的转座激活和可遗传DNA甲基化变异

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Differential histone modification marks of active versus repressed genes accompany these DNA methylation changes.

活化的差异组蛋白修饰标记物对抑制基因的改变伴随着这些DNA甲基化改变。

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Aging and Methylation of DNA

衰老与DNA甲基化

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